Innovation Theater 5 | Supported By: AstraZeneca

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Program Description

Is there more than one way to think about IL-33 in COPD?

Please join Monica Kraft, MD, for an engaging presentation discussing how the dual pathways of interleukin-33 (IL-33) may contribute to the pathogenesis of chronic obstructive pulmonary disease (COPD).

Inflammation, epithelial damage, and mucus dysfunction are central features of COPD. IL-33 is a cytokine expressed in the lung and released in response to epithelial injury. Two bioactive forms of IL-33 have been described, a reduced form and an oxidized form, which play distinct roles in driving inflammatory pathways and mucus dysfunction in COPD, respectively.

This session will explore:

• IL-33, a cytokine that can drive a broad spectrum of downstream host-response mechanisms in COPD
• The role of reduced IL-33 (IL-33 RED) as a driver of inflammation
• A novel mechanism in which oxidized IL-33 (IL-33 OX) drives airway epithelial damage and mucus dysfunction
• How dysregulation of the IL-33 pathways is associated with biological mechanisms of COPD and their potential clinical impact

Dr Monica Kraft is an internationally known physician-scientist who specializes in clinical and translational research in airway disease. She serves as System Chair of the Samuel Bronfman Department of Medicine, Murray M. Rosenberg Professor of Medicine, and Associate Dean for Clinical Affairs at the Icahn School of Medicine at Mount Sinai and Mount Sinai Health System. Dr Kraft’s work has appeared in journals such as The New England Journal of Medicine, The Journal of the American Medical Association, The Lancet, The Journal of Immunology, American Journal of Respiratory and Critical Care Medicine, and The Journal of Allergy and Clinical Immunology.

Ready to take a deeper dive into the pathobiology of inflammation and mucus dysfunction in COPD?

Discover the duality of IL-33 in COPD.

US-109691 Last Updated 3/26

Speakers

Presenter: Monica Kraft, MD
Mount Sinai Health
System Chair and Associate Dean
New York, New York