Innovation Theater 5
Supported By: Insmed

---

Program Description

Join Insmed for an Industry Theater presentation to learn more about bronchiectasis exacerbations and their management. Lunch will be provided. While bronchiectasis is often identified in patients with other lung diseases like COPD and asthma, it is a separate chronic lung disease usually marked by permanent, abnormal dilation and persistent inflammation of the airways. Patients with bronchiectasis often suffer from periods of worsening symptoms, or exacerbations, which can damage the lungs and contribute to the burden of the disease, affecting health-related quality of life.

In scientific literature, bronchiectasis has been characterized as a vicious cycle or vortex consisting of 4 primary drivers: chronic airway inflammation, impaired mucociliary clearance, lung destruction, and chronic airway infection. The role of inflammation in driving this condition continues to be a subject of research, with increasing evidence implicating neutrophilic inflammation in perpetuating the vicious vortex and contributing to recurrent damaging bronchiectasis exacerbations.

During this presentation, participants will explore the burdens and underlying causes of bronchiectasis exacerbations, with a particular focus on potential management strategies. This session will also delve into the key drivers of bronchiectasis, highlighting the critical role of inflammation in disease progression. Bronchiectasis experts will lead participants on a journey into the functions of the neutrophil, emphasizing how the mechanisms intended to defend against infection can, instead, be destructive during bronchiectasis. They will review data linking the inflammatory process to bronchiectasis exacerbations and worse clinical outcomes for patients with this disease.

To learn more about bronchiectasis and bronchiectasis exacerbations, join Insmed in the Exhibit Hall at Booth #2343. We are offering a variety of resources and events this year, including an immersive exhibit featuring bronchiectasis research, a 3D lung model, interactive explorations of the science, and more.

NP-BE-US-00433

Speakers

Panelist: George M. Solomon, MD, UAB
Division of Pulmonary, Allergy, and Critical Care Medicine. Director, UAB Adult PCD and Bronchiectasis Programs
University of Alabama at Birmingham
Birmingham, Alabama

Panelist: Colin Swenson, MD
Section Chief, Pulmonary and Critical Care
Director, NCFB/NTM Program
Emory Healthcare